Bioidentical Testosterone: The best male anti-aging tool the experts don’t want you to have – Dr Jonathan Wright

A useful and interesting article by this Harvard graduate, one of the fathers of bioidentical hormone therapy, in which the author claims:

For over 30 years, I’ve worked with men ages 45 and up whose symptoms and tests indicated a need for bio-identical testosterone. The results have been gratifying for everyone involved. Most notably, bio-identical testosterone therapy helps improve mood, attitude, cognitive ability, and general outlook on life. Many wives and families have observed that “Grandpa is a lot less grumpy,” remembers things better, and laughs and smiles a lot more often.

Plus, bio-identical testosterone improves muscle mass and strength, rebuilds bone, strengthens the heart and blood vessels, lowers total cholesterol and blood sugar, raises HDL (“good”) cholesterol, lowers blood pressure, lessens the chances of blood clots, improves tissue oxygenation, improves the health of a non-cancerous prostate gland-and that’s all before we get to testosterone’s positive effects on libido and your sex life.

The Non-Science Witch Hunt Against Hormone Replacement Therapies for Deficiency Syndromes Must End: An A4M Position Paper on Physician-Prescribed HRT

The first paragraph of this Position Paper from The American Academy of Anti-Aging Medicine (A4A), 23 September 2013, seems to describe just what is happening in Singapore at the moment. (Bolding by HCS)

Since the inception of the anti-aging medical movement in 1991, various establishment parties have ruthlessly leveraged their positions of power in academic, political, and regulatory arenas for the purpose of attempting to limit the use of hormone replacement therapies (HRT) in adults with documented clinical deficiencies. For over 15 years, a prolonged and calculated campaign of deceit, fraud, and suppression has threatened physician licensures and liberties to treat and prescribe life-improving therapies, leading potentially to the direct compromise of patients’ health and longevity. Dozens of physicians have been sanctioned and punished with loss of license and academic standing. This pernicious abuse of position and power is particularly prevalent with regard to RECENT challenges made against human growth hormone (HGH), testosterone (TRT), and DHEA replacement therapies that are trumpeted by the mainstream media. Biased reporters frequently – and inappropriately – demonize legitimate physicians and clinical compounding pharmacies who are reluctantly positioned on the frontline of a decades’ old agenda to limit freedom of choice and information, and the physician’s most essential responsibility to select the best course of therapy and medication for their patients. . . .


The American Academy of Anti-Aging Medicine (A4M), its numerous worldwide affiliated scientific and medical societies, and befriended organizations, supports the judicious application of modern and advanced medical technologies to address the changes in chemical, hormonal, physical, and nutritional needs that occurs with aging. Such repletion includes the restoration of hormones to an optimal physiological state when deficiency is determined by objective assessment.

Hormone replacement therapy (HRT) is an essential and extensively documented protocol for clinical intervention in the disorders of aging. HRT maintains an unblemished safety and efficacy profile that has been documented by 20 years of clinical application. Yet, a perfect storm of misguided media combined with biased parties whose livelihoods hinge on disparaging the anti-aging medical movement has grossly compromised access to HRT, placing the lives of hundreds of thousands of patients worldwide in potential jeopardy.

Experienced anti-aging physicians have been prescribing HRT for more than 20 years. PubMed contains more than 20,000 peer-reviewed studies of HRT, of which a preponderance document the life-enhancing and/or life extending benefits of HRT in aging adults. See Appendix A “Literature Review“ which presents a selection of such studies that represent the objective evidence that supports the A4M position.


Read the rest of the paper at:

Mainstream Medicine Still Struggles to Comprehend What Women Want

We thought one of the benefits of compounded hormone therapy was that it overcame concerns of overdosing or underdosing because it can be adjusted according to hormone levels in individual blood tests. The Endocrine Society seems not to agree . . .

Pharmacist survey shows huge growth in compounded menopausal hormone therapy 

6 March 2015, The Endocrine Society

Among prescriptions filled for menopausal hormone therapy (HT) in the U.S., almost half now are custom-compounded “bioidentical” hormones, according to analysis of a recent survey of nearly 500 pharmacists. The study results will be presented Friday March 6th at the Endocrine Society’s 97th annual meeting in San Diego.

Custom-compounded prescriptions, which are mixed for an individual according to a doctor’s prescription, are not well-regulated or monitored by the U.S. Food and Drug Administration (FDA).

“Despite the increased quality risks and the lack of safety and efficacy data for non-FDA regulated custom-compounded bioidentical hormones, their use by menopausal women is higher than expected and appears to be continuing to grow,” said lead researcher JoAnn Pinkerton, MD, a professor of obstetrics and gynecology at the University of Virginia Health System, Charlottesville.

Pinkerton cited statistics from Symphony Health Solutions that there were 36 million FDA-approved prescriptions filled for HT in 2012. That number is down 61 percent from the 93 million HT prescriptions filled in 2002.

Some postmenopausal women have been seeking alternatives to traditional hormone therapy since the Women’s Health Initiative study in 2002 linked it to certain increased health risks. Since then, customized bioidentical hormones have often been marketed as natural, safer alternatives to FDA-approved HT, with purported fewer side effects. However, according to the Endocrine Society, there is no scientific evidence supporting the safety or effectiveness of compounded bioidentical hormones.

Pinkerton and her colleagues analyzed results of a survey conducted last October on behalf of the International Journal of Pharmaceutical Compounding and in Thought Research, and sent to 12,250 pharmacists who provide compounding services. From 904 pharmacists who reported working at independent community pharmacies or independent compounding pharmacies, the number of completed survey responses totaled 483 (365 responses from community pharmacies and 118 from compounding pharmacies).

Based on the pharmacists’ responses of how many custom-compounded HT prescriptions they fill and the average percentage of compounding reported by the National Community Pharmacists Association and industry market research firm IBISWorld, the researchers estimated that 26 to 36 million total prescriptions custom-compounded HT were filled last year.

Of the responding pharmacists, 69 percent reported that they expected their HT compounding business to grow over the next two years. A greater proportion of compounding pharmacists anticipated growth than did community pharmacists: 75 percent versus 52 percent, respectively. Most pharmacists projected 5 to 25 percent growth of HT compounding by 2016, Pinkerton said.

In November of 2013, Congress passed the Drug Quality and Security Act (DQSA),14,15 which clarifies the FDA’s authority to enforce provisions of the Federal Food, Drug, and Cosmetic Act (FFDCA) that apply to pharmacy compounding. However, health providers and their patients should understand the differences in and the risks associated with less-regulated treatments of compounded menopausal hormone therapy,” she stated.

Possible risks of compounded HT, according to Pinkerton, include the lack of safety and efficacy data along with possible presence of contaminants and concerns of overdosing or underdosing.

Taken from:




Bioidentical Hormones – What you need to know

This very informative article is on the website of Dr Christiane Northrup, M.D. It deals with issues regarding the various “labels” used in the field of hormone replacement.

There seems to be a lot of confusion around the definition of “natural” versus “bioidentical” versus “synthetic” hormones. One thing to remember when making this distinction is that “bioidentical” refers to the shape of the molecule itself rather than the source of the hormone. By this, I mean that hormones can be marketed as “natural” or “plant-based,” yet not come near to being “bioidentical” to native human female hormones or performing as such in the body. Examples of this are the numerous proprietary HRT options being marketed as “plant-based” and “natural,” as well as purely yam-based creams.


Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study

Follow the link below to:

Effectiveness of Compounded Bioidentical Hormone Replacement Therapy: An Observational Cohort Study

Andres D Ruiz, Kelly R Daniels, Jamie C Barner, John J Carson and Christopher R Frei

BMC Women’s Health 2011, 11-27

This was an observational study of women between the ages of 18-89 who received a compounded BHRT product from January 1, 2003 to April 30, 2010 in six community pharmacies. It demonstrates that compounded BHRT improves mood symptoms. Larger studies are needed to examine the impact on vasomotor symptoms, myocardial infarction and breast cancer.